Study the Histopathological Effect Associated with Oral Overdose of Opioid Derivatives - on Liver and Kidney Tissue in Male Rats

The current study aimed to ascertain the impact of acute codeine dose (0.50 and 1 ml/ 250g), on histolopathological profile liver kidney in male rats. A synthetic antispasmodic substance with comparatively low toxicity is opioid derivatives (Codeine), In present results found that normal histological structure, except Some minor changes were shown control group (antihistamine syrup, which does not contain codeine), while groups II III overdose treatment reveal over involved inflammation cells infiltrations parenchyma, congestion blood vessel, fatty degeneration, cytoplasmic vacuolation, pyknotic hepatocytes nuclei. However, renal damage profiles seen kidneys treated rats, necrosis, degeneration lining tubules, enlarged lumen intracellular space. Red flooded intertubular gaps congested vessels. conclusion (Codeine) poisoning caused hepatocellular